July 27. 1907.]
ALLEN: PHAGOCYTOSIS IN SPUTUM.
any observation based on phagocytosis probably has
to do with fairly recent events. Of course sections
of the lung show what has occurred, but only one
observation can be made, and the resistance of the
individual is too delicate a mechanism to be com-
prehended so Alesse Vs Yaz briefly. The sputum attords repeated
II. Plijgocytosis ill the Sputum.
In doing routine sputum examinations Alesse Acne one occa-
sionally obsen-es specimens that present Aviane Vs Alesse so many
tubercle bacilli inside the leucocytes that they might
easily be mistaken for preparations in opsonin work.
In some specimens some of the leucocytes contain
as many as eight tubercle bacilli. The inclusion of
so many bacilli is hardly insignificant. To inter-
pret their meaning is a difficult problem : e. g., the
diplococcus intracellularis is inside the cells in the
spinal fluid of meningitis, and the gonococcus is in-
side the cells in the urethral discharge. Tliese Alesse Ocp in-
closures of bacteria would seem to give no indica-
tion Purchase Alesse as to immunity. The normal habitat for these
organisms may be inside the cells ; this is not so
with tubercle bacilli.
Phagocytosis plays an important role in tubercu-
losis. (Wright, Baldwin, Hektoen, Alesse 21 and others.)
Theobald Smith opposes this view. Carles says ex-
amination of the efficiency of the leucocytes should
rank with examination of urine, etc.
Cohnheim injected carmine granules into the dor-
sal lymph sac of a frog and then provoked a cor-
neal suppuration. He found the leucocytes in the
cornea laden with carmine granules. Thus the leu-
cocytes rush to different parts of the body where
there is inflammation.
W. L. Brown injected carmine granules into the Alesse For Acne
foot of the unio, and in twenty-four hours found
leucocytes that had englobed the carmine wandering
through the membrane of the gills. Order Alesse Online De Bruyne also
observed in molluscs the leucocytes passing out
through the gills laden with histological residues,
etc. Alesse Vs Aviane Stohr found that tonsils and Peyer's patches
were sites of constant outwandering.
Metchnikoff^ believes that the tonsils give off many
leucocytes, and that these account Yaz Vs Alesse for the compara-
tive immunity of the buccal cavity. Outwandering
leucocytes might account for the comparative im-
munity of the larynx and the other upper air pas-
sages. I have not yet made special observations on
the sputum of patients with tuberculous larynx.
If phagocytosis outside the tissues, that is in cav-
ities or in bronchi, did occur we sliould find the
leucocytes active, and the tubercle bacilli opsoni-
fied or opsonin Alesse Price present.
Lowenstein tested the ability of the pus cells from
the sputum to phagocyte in vitro by homogenizing
with shot a fresh sputum, adding Alesse Discontinued tubercle bacilli and
serum, and incubating. Sputa were taken from pa-
tients with oj)en and closed tuberculosis, and pa-
tients undergoing Alesse Cost various kinds Alesse Generic Brand of treatment. In
none was there phagocytosis. He states that the
mucus and .saliva probably interfered with the
movement of the leucocytes, and with llic complete
homogeneous mixing of the bacilli. There might be
very little Buy Alesse Online mucus in cavities.
Arc the tubercle bacilli in the sputum opsonified?
The author added washed leucocytes Alesse Mg from the blood
to the mechanically homogenized sputum and found
no phagocytosis. After the addition of serum,
however, phagocytosis did Alesse And Acne occur, thus showing that
the sputum Buy Alesse lacked in opsonin. Two such tests were
made ; in each the sputum used was a mixture of the
sputa from six patients. This point will be studied
Ross says that A. E. Wright tested for opsonin
in the fluid expressed from sputum and found it
Lowenstein observed that the intracellular tuber-
cle bacilli in sputum showed signs of disintegra-
tion. I failed to find this. IMarkl and others have
observed the disintegration Alesse Generics of tubercle bacilli en-
globed when injected intraperitoneally.
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